Janet Sinsheimer

Professor of Biostatistics, Biomathematics, & Human Genetics

Tel: (310) 825-3460 & (310) 825-8002		Room AV-321 CHS & 5357C Gonda
Fax: (310) 825-8685		Department of Biostatistics
		Department of Human Genetics
		UCLA School of Public Health
E-mail:janet@mednet.ucla.edu		Los Angeles, CA 90095-1772

Education

Sc.B. in Chemistry (1979) from Brown University.

M.A. in Biochemistry (1985) from Brandeis University, Waltham, MA.

M.S. in Biomathematics (1988) from UCLA.

Ph.D. in Biomathematics (1994) from UCLA.

Research & Interests

My research interests are in the statistical modeling of genetic and evolutionary data. In particular, I have been interested in the inference of evolutionary relationships using nucleotide sequence data and in statistical methods for locating disease genes.

Courses

Biostat M272 (formerly M237A)	Winter 2001, 02 & Fall 2004	Theoretical Genetic Modeling
Biostat M237 (formerly M237B)	Winter 2001, 02, 03, 04 & 06	Applied Genetic Modeling

Recent Publications

AConditional-on-exchangeable-parental-genotypes likelihood that remains
unbiased under multiple-affected-sibling ascertainment. P. Kraft, H-J
Hsieh, H. Cordell, J. Sinsheimer. Genetic Epidemiology 29: 87-90 (2005)

Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis
in a UK Caucasian population. Z. Mustafa, B. Dowling, K. Chapman,
J. Sinsheimer, A. Carr, J. Loughlin. Arthritis and Rheumatism 52:3502-3506 (2005).

Incorporating Serotypes into Family Based Association Studies using the MFG
Test. S. Minassian, C. G. S. Palmer, J. A. Turunen, T. Paunio, J.
Lonnqvist, L. Peltonen, J. A. Woodward, J. S. Sinsheimer. Annals of Human
Genetics 70: 541-553 (2006).

The CALM1 core promoter polymorphism associated with hip osteoarthritis in
Japanese is not associated with hip osteoarthritis in a United Kingdom Caucasian
population. J. Loughlin, J. S. Sinsheimer, A. Carr, K. Chapman. Osteoarthritis
and Cartilage 14: 295-298 (2006).

The v-MFG test: Investigating maternal, offspring, and maternal -fetal genetic
incompatibility effects on disease and viability. H-J. Hsieh, C.G.S. Palmer,
S.Harney, J. L. Newton, P. Wordsworth, M.A. Brown, J.S. Sinsheimer. Genetic Epidemiology
30:333-347 (2006).

Allowing for missing data at highly polymorphic genes when testing for maternal,
offspring and maternal-fetal genotype incompatibility effects. H-J. Hsieh, C. G. S. Palmer,
J. S. Sinsheimer. In press, Human Heredity.

HLA-B Maternal-fetal genotype matching increases risk for schizophrenia. C.
G. S. Palmer, H-J. Hsieh, E. F. Reed, J. Lonnqvist, L. Peltonen, J. A. Woodward,
J. S. Sinsheimer. In press, American Journal of Human Genetics.

Links

Statistical Genetics at UCLA

NIH Biosketch (MS Word)

Biomathematics