Janet Sinsheimer
Professor of Biostatistics, Biomathematics, & Human Genetics
Tel: (310) 825-3460 & (310) 825-8002
Fax: (310) 825-8685
Room AV-321 CHS & 5357C Gonda
Department of Biostatistics
Department of Human Genetics
Los Angeles, CA 90095-1772
E-mail:janet@mednet.ucla.edu
Education
Sc.B. in Chemistry (1979) from Brown University
M.A. in Biochemistry (1985) from Brandeis University, Waltham, MA
M.S. in Biomathematics (1988) from UCLA
Ph.D. in Biomathematics (1994) from UCLA
Research & Interests
My research interests are in the statistical modeling of genetic and evolutionary data. In particular, I have been interested in the inference of evolutionary relationships using nucleotide sequence data and in statistical methods for locating disease genes.
Courses
Biostat M272 (formerly M237A) Winter 2001, 02 & Fall 2004 Theoretical Genetic Modeling
Biostat M237 (formerly M237B) Winter 2001, 02, 03, 04 & 06 Applied Genetic Modeling
Recent Publications
AConditional-on-exchangeable-parental-genotypes likelihood that remains unbiased under multiple-affected-sibling ascertainment. P. Kraft, H-J Hsieh, H. Cordell, J. Sinsheimer. Genetic Epidemiology 29: 87-90 (2005)
Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population. Z. Mustafa, B. Dowling, K. Chapman, J. Sinsheimer, A. Carr, J. Loughlin. Arthritis and Rheumatism 52:3502-3506 (2005).
Incorporating Serotypes into Family Based Association Studies using the MFG Test. S. Minassian, C. G. S. Palmer, J. A. Turunen, T. Paunio, J. Lonnqvist, L. Peltonen, J. A. Woodward, J. S. Sinsheimer. Annals of Human Genetics 70: 541-553 (2006).
The CALM1 core promoter polymorphism associated with hip osteoarthritis in Japanese is not associated with hip osteoarthritis in a United Kingdom Caucasian population. J. Loughlin, J. S. Sinsheimer, A. Carr, K. Chapman. Osteoarthritis and Cartilage 14: 295-298 (2006).
The v-MFG test: Investigating maternal, offspring, and maternal -fetal genetic incompatibility effects on disease and viability. H-J. Hsieh, C.G.S. Palmer, S.Harney, J. L. Newton, P. Wordsworth, M.A. Brown, J.S. Sinsheimer. Genetic Epidemiology 30:333-347 (2006).
Allowing for missing data at highly polymorphic genes when testing for maternal, offspring and maternal-fetal genotype incompatibility effects. H-J. Hsieh, C. G. S. Palmer, J. S. Sinsheimer. In press, Human Heredity.
HLA-B Maternal-fetal genotype matching increases risk for schizophrenia. C. G. S. Palmer, H-J. Hsieh, E. F. Reed, J. Lonnqvist, L. Peltonen, J. A. Woodward, J. S. Sinsheimer. In press, American Journal of Human Genetics.
Links
NIH Biosketch (MS Word)